News & Events - Patents, Presentations, News Articles & Publications

Aryl Imidazole and Aryl Oxazole Carboxamides for Treating Multiple Sclerosis. WO2010055304

Cambridge News, "High Hopes for New Sareum Cancer Drug". Link to on-line article 16 August 2011
Cambridge News, "Star Status for Sareum". Link to on-line article 6 July 2011
Interactive Investor, "AIM Winners and Losers (01/01 - 30/06/11)". Link to on-line article 5 July 2011
Cambridge News, "Tenfold Growth in Two Months". Download PDF or Link to on-line article 24 May 2011

Publications related to Sareum programmes

Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing. JC Reader, TP Matthews, S Klair, K-MJ Cheung, J Scanlon, N Proisy, G Addison, J Ellard, N Piton, S Taylor, M Cherry, M Fisher, K Boxall, S Burns, MI Walton, IM Westwood, A Hayes, P Eve, M Valenti, A de Haven Brandon, G Box, RLM van Montfort, DH Williams, GW Aherne, FI Raynaud, SA Eccles, MD Garrett and Ian Collins, J. Med. Chem., 2011, 54 (24), 8328–8342. Abstract

CCT244747 is a novel, potent and selective inhibitor of CHK1 with oral efficacy both alone in neuroblastoma and in combination with genotoxic chemotherapeutic agents. MI. Walton, PE. Eve, A Hayes, MR. Valenti, AK. de Haven Brandon, G Box, A Hallsworth, EL. Smith, KJ. Boxall, M Lainchbury, TP. Matthews, Y Jamin, SP Robinson, GW Aherne, JC. Reader, L Chesler, FI. Raynaud, SE Eccles, I Collins, MD Garrett, AACR NCI EORTC “Molecular Targets and Cancer Therapeutics”, San Francisco, CA, Nov 12-16, 2011 Abstract

Structure-Guided Evolution of Potent and Selective Oral Inhibitors of CHK1 through Scaffold Morphing. TP Matthews, S Klair, K-MJ Cheung, J Scanlon, M Lainchbury, N Piton, M Fisher, M Cherry, K Boxall, MI. Walton, IM Westwood, A Hayes, P Eve, M Valenti, A de Haven Brandon, G Box, RLM van Montfort, DH. Williams, W Aherne, FI Raynaud, SA Eccles, MD Garrett, JC. Reader, I Collins,.AACR NCI EORTC “Molecular Targets and Cancer Therapeutics”, San Francisco, CA, Nov 12-16, 2011 Abstract

Design and Evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as Inhibitors of Checkpoint and Other Kinases. Matthews, T.P., McHardy, T., Klair, S., Boxhall, K., Fisher, M., Cherry, M., Allen, C.E., Addison, G.J., Ellard, J., Aherne, G.W., Westwood, I.M, van Montfort, R., Garrett, M.D., Reader, J.C. & Collins, I., Bioorg & Med Chem Lett (2010), 20(14), 4045-4049. Abstract

The Preclinical Pharmacology and Therapeutic Activity of the Novel CHK1 Inhibitor SAR-020106. Walton, M.I., Eve, P.D., Hayes, A., Valenti, M., De Haven Brandon, A., Box, G., Boxall, K.J., Aherne, G.W., Eccles, S.A., Raynauld, F.I., Williams, D.H., Reader, J.C., Collins, I., Garrett, M.D., Mol Cancer Ther (2010), 9(1), 89-100. Abstract

Identification of Inhibitors of Checkpoint Kinase 1 through Template Screening. Matthews, T.P., Klair, S., Burns, S., Boxall, K., Cherry, M., Fisher, M., Westwood, I.M., Walton, M.I., McHardy, T., Kwai-Ming, J.C., Van Montfort, R., Williams, D., Aherne, G.W., Garrett, M.D., Reader, J and Collins, I, J Medicinal Chemistry (2009), 52(15), 4810-4819. Abstract

Identification and Structure-guided Optimisation of Novel Inhibitors of Checkpoint Kinase 1 (Chk1) through Combined Biochemical and Crystallographic Screening. Reader, J., Williams, D., Klair, S., Cherry, M., Fisher, M., Scanlon, J., Piton, N., Addison, G., Lamers, M., et al. AACR Annual Meeting, San Diego, CA, Apr 12-16, 2008. Download PDF

Publications related to Sareum expertise

A New Regulatory Switch in a JAK Protein Kinase. Tsui, V., Gibbons, P., Ultsch, M., Motara, K., Chang, C., Blair, W., Pulk, R., Stanley, M., Starovasnik, M., Willimas, D., Lamers, M., Leonard, P., Magnuson, S., Liang, J. & Eigenbrot, C, Proteins: Structure, Function & Bioinformatics (2011) 79(2), 393-401. Abstract

Introduction to Fragment-based Drug Discovery, T Mitchell & M Cherry in “Fragment-Based Drug Discovery: Practical Aspects”, E.R. Zartler & M.J. Shapiro, Eds, John Wiley & Sons (2008). Buy at Amazon

Finding protein kinase hits using structural information. Cherry, M., Reader, J. and Williams, D.H. Prog. Med. Chem., (2006). 44, 1-63.

Fragment-Based Drug Design, Mitchell, T. and Cherry, M. Innovations in Pharmaceutical Technology, (2005). 16, 34-36. Download PDF

The design of a new potent and selective ligand for the BRS3 receptor. Boyle, R.G., Humphries, J., Mitchell, T., Showell, G.A., Iijima, H., Shimada, H., Arai, T., Ueno, H., Usui, H., Sakaki, T., Wada, E. and Wada, K. J Peptide Research, (2005). 11(3), 136-141.

Automation in medicinal chemistry. Reader, John C. Current Topics in Medicinal Chemistry, (2004), 4(7), 671-686.

Solid phase synthesis of tetrahydro-1,4-benzodiazepin-2-ones. Hone, Neal D.; Wilson, William; Reader, John C. Tetrahedron Letters, (2003). 44(46), 8493-8495.

Solid-phase synthesis of dibenzoxazepinones. Hone, Neal D., Salter, James I., Reader, John C. Tetrahedron Letters, (2003). 44(44), 8169-8172.

Reusable resin plug-bound palladium catalysts for organic synthesis. Atrash, B., Reader, J. and Bradley, M. Tetrahedron Letters, (2003). 44(25), 4779-4782.

Descriptors, Physical Properties and Drug-Likedness. Brüstle, M., Beck, B., Schindler, T., King, W., Mitchell, T. and T. Clark, T. J. Med. Chem., (2002). 45(16), 3345-3355.

Latest developments in crystallography and structure-based design of protein kinase inhibitors as drug candidates. Williams, D.H. and Mitchell T. Curr Opin. Pharmacology, (2002). 2, 567-573.

Design, Synthesis, and Biological Evaluation of a Library of 1-(2-Thiazolyl)-5-(trifluoromethyl)pyrazole-4-carboxamides. Donohue, B.A., Michelotti, E.L., Reader, J.C., Reader, V., Stirling, M. and Tice, C.M. Journal of Combinatorial Chemistry, (2002). 4(1), 23-32.

Design Strategies for building drug-like chemical libraries. Mitchell, T. & Showell, G. Curr. Opin. Drug Disc. Dev., (2001). 4(3), 314-318.

Revolutionizing resin handling for combinatorial synthesis. Atrash, B., Bradley, M., Kobylecki, R., Cowell, D. and Reader, J. Angewandte Chemie, International Edition, (2001). 40(5), 938-941.